The Leafs currently have 7 NHL defensemen on the roster in
Morgan Rielly,
T.J. Brodie,
Jake McCabe, John Klingberg, Mark Giordano,
Timothy Liljegren and
Conor Timmins. It's very likely that someone from this list is moved to accommodate someone bigger and nastier coming in. We can probably rule out Morgan Rielly, who has a full NMC, and John Klingberg, who was just signed. McCabe also seems unlikely to move, given his value and term versus some of the other options. So that leaves Brodie, Giordano, Liljegren and Timmins as possible assets to move.